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Abstract #0994

A Spatiotemporal Explainable Model for Predicting Pathological Complete Response to Neoadjuvant Chemotherapy Using Breast DCE-MRI

Hui Yang1,2, Ya Ren3, Meng Wang3, Dehong Luo3, Wei Cui4, Zhanli Hu1,5, Zhou Liu3, and Na Zhang1,5
1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, ShenZhen, China, 2College of Auomation Engineering, Nanjing University of Aeronautics and Astronautics, NanJing, China, 3Department of Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital \& Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, ShenZhen, China, 4GE Healthcare, MR Research China, BeiJing, China, 5Key Laboratory of Biomedical Imaging Science and System, Chinese Academy of Sciences, ShenZhen, China

Synopsis

Keywords: Diagnosis/Prediction, Breast

Motivation: Current MRI-based deep learning approaches for predicting pathological complete response (pCR) often fail to fully leverage 3D spatial information and temporal relationships, limiting their predictive accuracy and interpretability.

Goal(s): We propose ATVE-3DCNN, an Adaptive Thresholding and Visually Explainable 3D CNN,to improve pCR prediction and interpretability.

Approach: We design multiscale modules to capture local and global feature in 3D space. Pre- and post-treatment features are combined to model temporal relationships. Finally, we utilize 3D Grad-CAM for interpretability.

Results: Validated on a public dataset, our method achieve median AUC of 75.61%, accuracy of 75.41%, sensitivity of 70%, and specificity of 80.49%.

Impact: This proposed method provides a more comprehensive understanding of the dynamic changes within the tumor, thereby improving the effectiveness of response assessment and offering valuable technical support for predicting neoadjuvant chemotherapy efficacy in breast cancer.

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