Keywords: Diagnosis/Prediction, Breast
Motivation: Current MRI-based deep learning approaches for predicting pathological complete response (pCR) often fail to fully leverage 3D spatial information and temporal relationships, limiting their predictive accuracy and interpretability.
Goal(s): We propose ATVE-3DCNN, an Adaptive Thresholding and Visually Explainable 3D CNN,to improve pCR prediction and interpretability.
Approach: We design multiscale modules to capture local and global feature in 3D space. Pre- and post-treatment features are combined to model temporal relationships. Finally, we utilize 3D Grad-CAM for interpretability.
Results: Validated on a public dataset, our method achieve median AUC of 75.61%, accuracy of 75.41%, sensitivity of 70%, and specificity of 80.49%.
Impact: This proposed method provides a more comprehensive understanding of the dynamic changes within the tumor, thereby improving the effectiveness of response assessment and offering valuable technical support for predicting neoadjuvant chemotherapy efficacy in breast cancer.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords