Abstract #0996

Relaxation-selective IVIM imaging of Microvascular Perfusion and Fluid Compartments in the Human Choroid Plexus

Chenyang Li^1,2, Zhe Sun^1,2, Jiangyang Zhang^1,2, and Yulin Ge^1,2

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ²Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: IVIM, IVIM, Choroid Plexus, Relaxation, Interstitial Fluids, Microvascular Perfusion

Motivation: Non-invasive assessment of choroid plexus (ChP) perfusion and fluid compartments is important to assess the production of cerebrospinal fluid and waste clearance.

Goal(s): To develop a relaxation selective intravoxel incoherent motion (IVIM) technique to assess the capillary perfusion and fluids compartments within the ChP.

Approach: IVIM imaging with T₁ and T₂ selection.

Results: Conventional IVIM imaging showed three fluids compartments in the ChP, corresponding to tissue, CSF, and capillary blood. FLAIR-IVIM revealed an interstitial fluids (ISF) compartment. Further study showed older adults had increased ChP volume, reduced microvascular perfusion, and decreased ISF volume compared to young adults.

Impact: This study demonstrates a novel IVIM approach with T₁ and T₂ selection. It can assess the ChP structure and perfusion, which can potentially be used to evaluate age-related changes in its fluid compartments, such as microvascular perfusion and ISF volume.

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