Abstract #0999

Investigating Choroid Plexus Subcompartments in Aging and Premanifest Synucleinopathy Using 7 Tesla MRI

Firdaus Fabrice Hannanu¹, Kavita Singh², Guadalupe Garcia-Gomar³, Stephan Grimaldi⁴, Subhranil Koley¹, Ambra Stefani⁵, Aleksandar Videnovic^6,7, and Marta Bianciardi^1,6

¹Radiology, Brainstem Imaging Laboratory, Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, ²Multiscale Imaging and Integrative Biophysics Unit, LBN, National Institute on Aging, NIH, Baltimore, MD, United States, ³Escuela Nacional de Estudios Superiores Unidad Juriquilla, Universidad Nacional Autónoma de México, Queretaro, Mexico, ⁴APHM, Hôpital Universitaire Timone, Deparitment of Neurology and Movement Disorders, Marseille, France, ⁵Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria, Innsbruck, Austria, ⁶Division of Sleep Medicine, Harvard University, Boston, Massachusetts, USA, Boston, MA, United States, ⁷Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA, Boston, MA, United States

Synopsis

Keywords: Aging, Tissue Characterization, Choroid Plexus

Motivation: Alterations in the choroid plexus (ChP) may impair the cerebrospinal fluid waste-clearance system, contributing to aging and, in premanifest synucleinopathy, to neurotoxic α-synuclein accumulation; however, these mechanisms remain underexplored.

Goal(s): To classify ChP sub-compartments (stromal tissue/vessels, cysts) and assess their structural changes in aging and premanifest synucleinopathy.

Approach: Using multi-contrast 7 Tesla MRI, we segmented ChP sub-compartments in younger/older controls (YCON/OCON), and in premanifest synucleinopathy (iRBD).

Results: Total ChP, stromal tissue and vessel volumes increased with age, but not in iRBD. Cyst volumes remained stable. Mean T₁-weighted signal decreased with age. iRBD exhibited higher T₁-weighted signal variability in ChP and stromal tissue.

Impact: Findings reveal age-related ChP sub-compartment volume and signal changes, with increased heterogeneity in iRBD indicating disrupted structural integrity. ChP sub-compartment analysis enhances understanding of ChP's role in aging and synucleinopathies, potentially aiding biomarker development.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.