Abstract #1007

Synthesized skull properties relate to functional changes at rest due to low-intensity focused ultrasound stimulation on M1

Kai-Hsiang Stanley Chen¹, Wei-Chih Yang^2,3, Hao-Li Liu⁴, Yih-Chih Jacinta Kuo¹, Yan-Siou Dong¹, and Yao-Chia Shih³

¹Department of Neurology, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu City, Taiwan, ²Department of Medical Imaging, National Taiwan University Hospital, Taipei City, Taiwan, ³Graduate Institute of Medicine, Yuan Ze University, Taoyuan City, Taiwan, ⁴Department of Electrical Engineering, National Taiwan University, Taipei City, Taiwan

Synopsis

Keywords: Task/Intervention Based fMRI, Other Interventional

Motivation: The effectiveness of low-intensity continuous-theta-burst transcranial focused ultrasound stimulation (ctbTUS) influenced by skull homogeneities is unclear, especially without computed tomography (CT) scans.

Goal(s): Uncovering relationships of deep-learning-derived T1-based-pseudo-CT skull properties and transducer-scalp-gap space with M1-functional-connectivity (M1-FC) changes induced by ctbTUS.

Approach: Twenty healthy volunteers’ 3D T1-weighted images were used to estimate transducer-scalp gap space and synthesize pseudo-CT information to correlate with M1-FC changes.

Results: ctbTUS-induced FC changes within the left M1 significantly related to skull bone density and transducer-scalp gap space (adjusted-R²=0.509, p= 0.024).

Impact: Shedding light on the feasibility of T1-based-pseudo-CT skull properties to predict neuromodulatory effect of ctbTUS.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.