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Abstract #1010

Ketosis Elevates Antioxidants and Enhances Neural Function Through Improved Bioenergetics: A 1H MR Spectroscopy Study

Helena van Nieuwenhuizen1,2, Botond B. Antal2,3, Antoine Hone-Blanchet2, Andrew Lithen2, Liam McMahon2, Sofia Nikolaidou2, Zeming Kuang2,3, Kieran Clarke4, Bruce G. Jenkins2, Douglas L. Rothman5,6, Lilianne R. Mujica-Parodi1,2,3,7, and Eva-Maria Ratai2
1Physics, Stony Brook University, Stony Brook, NY, United States, 2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, 3Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, 4Physiology, Oxford University, Oxford, United Kingdom, 5Radiology, Yale University, New Haven, CT, United States, 6Biomedical Engineering, Yale University, New Haven, CT, United States, 7Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, United States

Synopsis

Keywords: Aging, Metabolism, Ketosis, Bioenergetics

Motivation: Ketosis offers benefits to brain health across a range of diseases and disorders.

Goal(s): Ketosis alters levels of neuroactive amino acids and enhances neural function. Its influence on other metabolites, and how ketosis improves neural function, remain unclear.

Approach: In a within-subjects design (N=63), we measured the neurochemical effects of acute ketosis on the human brain using 7T 1H MRS and the impact on neural function using rsfMRI.

Results: Ketones, but not glucose, elevated antioxidants and energy markers while altering E/I neurotransmitter ratios. Higher fasting Glc levels were associated with increased neuroinflammation markers. Increased bioenergetics correlated with greater improvements in neural function.

Impact: The combination of metabolic and functional neuroimaging data in our study provides a comprehensive view of how ketosis affects brain chemistry and functional network dynamics, offering insights for developing novel treatment strategies for a variety of psychiatric and neurodegenerative disorders.

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Keywords