Keywords: Kidney, Kidney, fibrosis
Motivation: In chronic kidney disease, renal fibrosis is characterized by excessive accumulation of extracellular matrix proteins, leading to a magnetization transfer (MT) effect. Previous animal studies indicated the potential of MT for assessing renal fibrosis.
Goal(s): To investigate the clinical significance of MT imaging for assessing renal fibrosis and to compare its efficacy with T1 mapping.
Approach: Twenty subjects were recruited, with data collected using two-dimensional breath-hold MTR and T1 mapping techniques. Statistical analysis were conducted with p<0.05.
Results: Significant differences in T1 values were found between the control and patient groups; however, no significant differences in MTR were observed between the groups.
Impact: This study found no significant difference in MTR between groups with and without renal fibrosis. Future research using quantitative MT imaging techniques on a larger cohort is warranted to understand the clinical utility of MT effect in assessing renal fibrosis.
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