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Abstract #1018

MR Diffusion Models for Non-invasively Assessing Renal Interstitial Fibrosis and Annual Renal Function Loss in Chronic Kidney Disease

Guanjie Yuan1, Zhouyan Liao1, Ping Liang1, Ting Yin2, Wei Chen2, Chuou Xu1, and Zhen Li1
1Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan,Hubei, China, 2MR Research Collaborations, Siemens Healthineers Ltd., China, China

Synopsis

Keywords: Kidney, Kidney, Diffusion Weighted Imaging; Chronic Kidney Disease; Interstitial Fibrosis; Progression.

Motivation: Non-invasive and reliable biomarkers for grading interstitial fibrosis (IF) and predicting progression of chronic kidney disease (CKD) are needed.

Goal(s): To explore the effectiveness of seven diffusion models (DWI, IVIM, DKI, CTRW, FROC, SEM, and sADC) in assessing renal IF and annual renal function loss in CKD.

Approach: The performances of diffusion models in distinguishing between mild and moderate-to-severe IF were evaluated. The association between diffusion metrics and estimated glomerular filtration rate (eGFR) slopes were investigated.

Results: Combined model of cortical fIVIM, MKDKI and eGFR outperformed individual clinical model in grading IF, with cortical fIVIM and αSEM as potential biomarkers for CKD progression.

Impact: This study identifies the optimal diffusion metrics for grading renal IF and predicting short-term progression of CKD, aiding in the guidance of personalized management and the prevention of poor outcomes.

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Keywords