Keywords: Kidney, Elastography, hepatorenal syndrome (HRS), Renal injury, Dual-Frequency, Chronic Liver Disease
Motivation: Simultaneous dual-frequency 3D magnetic resonance elastography (Sd-3D MRE) can acquire data at two frequencies in one acquisition, which may be useful for the diagnosis and monitoring of renal impairment
Goal(s): To assess the performance of a Sd-3D MRE technique for detecting renal injury in patients with cirrhosis
Approach: Sd-3D MRE was used to obtain multiple parameters reflecting kidney tissue mechanical properties to evaluate renal injury
Results: MRE-measured renal stiffness (RS) at 60Hz and 120Hz showed excellent diagnostic performance for distinguishing HRS patients from non-HRS patients (AUC=0.888 and 0.925, respectively). RS at 120Hz also effectively differentiated non-HRS renal insufficiency patients from healthy controls (AUC=0.762).
Impact: Simultaneous dual-frequency 3D MRE can differentiate HRS in patients with advanced chronic liver disease and can distinguish renal injury before the onset of HRS and shorten the acquisition time.
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