Meeting Banner
Abstract #1025

Fatty acid composition MRI at 1.5T identifies novel epicardial adipose tissue biomarkers of impaired myocardial perfusion in women with ANOCA

John Echols1, Nisha Hosadurg2, Shuo Wang2, Bishow Paudel2, Amit Patel2, Patricia Rodriguez Lozano2, and Frederick Epstein1
1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 2Division of Cardiovascular Medicine, University of Virginia, Charlottesville, VA, United States

Synopsis

Keywords: Heart Failure, Heart

Motivation: Epicardial adipose tissue (EAT) plays a key role in metabolic inflammation affecting cardiovascular health. Identifying biomarkers of proinflammatory EAT could enhance understanding of impaired microvascular function in women with angina but no obstructive coronary artery disease (ANOCA).

Goal(s): This study aims to evaluate EAT fatty acid composition (FAC) and its relationship to myocardial perfusion reserve (MPR) in female ANOCA patients.

Approach: Correlations were assessed between MPR and EAT fatty acid fractions quantified using our novel MRI method.

Results: Results showed MPR correlates positively with polyunsaturated fatty acids, and negatively with saturated fatty acids, suggesting FAC as a biomarker of proinflammatory EAT.

Impact: This study introduces EAT FAC imaging at 1.5T as a potential mechanism of microvascular dysfunction to further investigate in women with ANOCA.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords