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Abstract #1030

Advances in free-breathing 3D cardiac MR elastography via TURBINE-MRE

Nolan Meyer1, Yi Sui1, Jessica Magnuson1, Phillip Rossman1, Kevin Glaser1, Matthew Murphy1, Armando Manduca1,2, Ian Chang3, Kiaran McGee1, Kejal Kantarci1, Ekta Kapoor4, Philip Araoz1, Richard Ehman1, Joshua Trzasko1, and Arvin Arani5
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN, United States, 3Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States, 4Women's Health Research Center, Mayo Clinic, Rochester, MN, United States, 5Radiology, Mayo Clinic, Jacksonville, FL, United States

Synopsis

Keywords: Myocardium, Cardiovascular

Motivation: Quantitative myocardial stiffness has considerable value as a clinical and scientific metric, but is difficult to measure. Current imaging strategies require breath-holds, limiting application across patient and volunteer cohorts.

Goal(s): To develop a free-breathing MR elastography (MRE) technique enabling whole-heart stiffness estimation across multiple phases of the cardiac cycle.

Approach: A 3D TURBINE-MRE acquisition was combined with electrocardiogram and respiratory belt data, retrospective data binning, and iterative reconstruction.

Results: Stiffness estimation with whole-heart coverage through 7 cardiac phases was demonstrated with a 10-minute scan in 9 volunteers. Change in left-ventricular stiffness was measured throughout the cardiac cycle.

Impact: MRI-derived measures of myocardial mechanical properties have important clinical and scientific applications, but are predominantly measured with breath-held scans and limited geometries, or invasively. This work demonstrates free-breathing elastography of the whole heart, enabling broader application and analysis.

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