Abstract #1032

Clinical Validation of a Wideband Perfusion Pulse Sequence: Myocardial Blood Flow Quantification in Patients with a CIED during stress and at rest

Lexiaozi Fan¹, Dima Bishara^1,2, Maria Davo Jimenez³, Jacqueline Urban³, Kyungpyo Hong¹, Jeremy D. Collins⁴, Li-Yueh Hsu⁵, Shuo Wang⁶, Amit R. Patel⁶, Cagdas Topel³, Oluyemi B. Aboyewa^1,2, Daniel C. Lee³, and Daniel Kim^1,2

¹Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, ²Department of Biomedical Engineering, Northwestern University, Evanston, IL, United States, ³Department of Medicine (Cardiology), Northwestern University Feinberg School of Medicine, Chicago, IL, United States, ⁴Department of Radiology, Mayo Clinic, Rochester, MN, United States, ⁵Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States, ⁶Division of Cardiovascular Medicine, University of Virginia Health System, Charlottesville, VA, United States

Synopsis

Keywords: Myocardium, Perfusion, Cardiac Implantable Electronic Devices, Ischemia

Motivation: Although wideband perfusion sequences have shown effectiveness in quantifying myocardial-blood-flow (MBF) at rest in patients with cardiac-implantable-electronic-devices (CIEDs), their utility during vasodilator stress remains unproven.

Goal(s): To clinically validate whether stress-rest MBF quantification derived from a 6-fold-accelerated wideband perfusion sequence is able to detect myocardial ischemia in patients with implantable-cardioverter-defibrillators (ICDs).

Approach: We enrolled 21 patients with ICDs and 11 ICD simulated control patients with no coronary-artery-disease (CAD) using the wideband perfusion sequence during adenosine stress and at rest, calculated and compared stress-rest MBF and myocardial-perfusion-reserve (MPR) values.

Results: Stress MBF and MPR values were significantly lower in patients with ICDs than controls.

Impact: This study validates that a 6-fold accelerated wideband perfusion pulse sequence produces meaningful stress MBF and MPR measurements for detecting myocardial ischemia in patients with ICDs.

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