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Abstract #1038

Unveiling Fetal Cortical Folding: Neuroimaging and Genetic Insights

Xinyi Xu1, Ruike Chen1, Tianshu Zheng1, Zhiyong Zhao1, Mingyang Li1, and Dan Wu1
1Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China

Synopsis

Keywords: Fetal, Normal development, Brain; Cortical Folding; Gene Expression; In-utero MRI; Atlas

Motivation: Understanding the genetic mechanisms that govern cortical folding is essential for uncovering the biological processes that drive early brain development.

Goal(s): To identify gene sets associated with structural and microstructural characteristics of the fetal cortical folding.

Approach: We combined advanced in-utero structural MRI and diffusion MRI measurements of cortical curvature and microstructure with PsychEncode gene expression data, examining correlations across cortical regions during key developmental stages.

Results: Our analysis identified gene sets associated with cortical folding. Genes linked to neurogenesis, neuron differentiation, cell adhesion, and extracellular matrix development, indicating their roles in fetal cortical development.

Impact: This research links specific genes to fetal cortical folding, offering insights into prenatal brain development and potential biomarkers for early neurodevelopmental disorder detection. These findings enable further study of gene-environment interactions, advancing diagnostic and therapeutic approaches.

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