Abstract #1040

ASL perfusion MRI in neonates less than one week of age: arterial suppression and vector-projection-based CBF estimation

Zhiyi Hu¹, Jennifer Shepard², Melike Guryildirim³, Yuto Uchida³, Kenichi Oishi³, Wen Shi⁴, Peiying Liu⁵, Vivek Yedavalli³, Aylin Tekes³, Doris Lin³, W. Christopher Golden², and Hanzhang Lu^3,4,6

¹Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Eudowood Neonatal Pulmonary Division, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ⁶F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States

Synopsis

Keywords: Neonatal, Perfusion

Motivation: Arterial-spin labeling (ASL) MRI in newborns less than one week of age is arguably the most challenging application of ASL.

Goal(s): To develop an ASL scheme that provides high-fidelity perfusion maps while minimizing noise and biases.

Approach: We developed a projection-based data processing method to reduced CBF overestimation, and verified its efficacy using simulation, phantom and neonatal ASL data. We further identified optimal arterial saturation to suppress pulsation noise while preserving SNR.

Results: Projection-based complex-subtraction method can mitigate perfusion overestimation bias. Arterial saturation with a 15 cm/s cutoff velocity effectively reduced large-vessel signal fluctuations without affecting tissue perfusion signal.

Impact: Using the proposed ASL acquisition and processing method, high-fidelity perfusion maps can be obtained from early neonates in less than 4 minutes. This technique holds potentials for studying neonatal brain diseases involving perfusion abnormalities.

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