Abstract #1055

Impact of Frontotemporal Dementia on the Coupling of Cerebral Energy Metabolism to Neuronal Activity: A hybrid PET/MR study

Mathew Joshy^1,2, Praveen Dassanayake^1,2, Linshan Liu², Marco Aiello³, Udunna Anazodo^2,4, Elizabeth Finger⁵, and Keith St. Lawrence^1,2

¹Department of Medical Biophysics, University of Western Ontario, London, ON, Canada, ²Lawson Research Institute, London, ON, Canada, ³Istituto di Ricerca Diagnostica e Nucleare, Naples, Italy, ⁴Montreal Neurological Institute, McGill University, Montreal, QC, Canada, ⁵Department of Clinical Neurological Sciences,, University of Western Ontario, London, ON, Canada

Synopsis

Keywords: Dementia, PET/MR, Metabolism; FDG

Motivation: Relationship between cerebral glucose metabolism and functional connectivity is impaired in neurodegenerative disorders, though complexities related to multimodal data requirements have limited investigations to Alzheimer’s

Goal(s): To investigate the impact of frontotemporal dementia on functional-metabolic coupling within resting state networks.

Approach: Hybrid PET/MRI was used to collect data on metabolism (FDG-PET) and connectivity (fMRI) in frontotemporal dementia patients and age-matched healthy controls.

Results: Dissociation between metabolism and functional connectivity was observed in resting state networks most associated with frontotemporal dementia

Impact: Decoupling of cerebral glucose metabolism and functional connectivity is not limited to Alzheimer's, but evident in other neurodegenerative conditions. This dissociation is most associated with resting state networks impacted by the specific condition.

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