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Abstract #1063

Which Came First: Ventricular Enlargement or Abnormal CSF Circulation?

Pan LIU1,2, Jiachen Xie1, Yann Attekeble3, Kimi Owashi1, and Olivier Balédent1,2
1CHU Amiens-Picardie, University Hospital, Amiens, France, 2CHIMERE EA.7516, Amiens, France, 3University of Lille, Lille, France

Synopsis

Keywords: Dementia, Neurofluids, Hydrocephalus, CSF Circulation, Brain Morphology, Biomarkers

Motivation: Hydrocephalus involves ventricular enlargement and abnormal CSF circulation. Determining their sequence is crucial for understanding pathogenesis and improving diagnosis.

Goal(s): Validate that area ratio of lateral ventricles to brain (Ratio-Area) and stroke volume ratio of aqueduct to spinal canal (Ratio-SV) are reliable markers, and explore the pathogenesis of communicating hydrocephalus.

Approach: Thirty-six healthy volunteers underwent MRI to extract morphological and fluid dynamics parameters, analysing correlations among aqueduct Resistance, Ratio-Area, and Ratio-SV.

Results: Ratio-Area and Ratio-SV eliminate the influence of heart rate, CSF volume, and brain volume differences. No correlation between Ratio-Area and Ratio-SV, while Resistance showed a strong correlation with Ratio-SV.

Impact: The findings provide insights into the pathogenesis of hydrocephalus, offering potential markers for early diagnosis. Understanding the relationship between aqueduct resistance, Ratio-SV, and Ratio-Area may guide clinical practice and help identify early indicators of CSF dynamic disorders.

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