Keywords: Dementia, Neurofluids, Hydrocephalus, CSF Circulation, Brain Morphology, Biomarkers
Motivation: Hydrocephalus involves ventricular enlargement and abnormal CSF circulation. Determining their sequence is crucial for understanding pathogenesis and improving diagnosis.
Goal(s): Validate that area ratio of lateral ventricles to brain (Ratio-Area) and stroke volume ratio of aqueduct to spinal canal (Ratio-SV) are reliable markers, and explore the pathogenesis of communicating hydrocephalus.
Approach: Thirty-six healthy volunteers underwent MRI to extract morphological and fluid dynamics parameters, analysing correlations among aqueduct Resistance, Ratio-Area, and Ratio-SV.
Results: Ratio-Area and Ratio-SV eliminate the influence of heart rate, CSF volume, and brain volume differences. No correlation between Ratio-Area and Ratio-SV, while Resistance showed a strong correlation with Ratio-SV.
Impact: The findings provide insights into the pathogenesis of hydrocephalus, offering potential markers for early diagnosis. Understanding the relationship between aqueduct resistance, Ratio-SV, and Ratio-Area may guide clinical practice and help identify early indicators of CSF dynamic disorders.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords