Keywords: Breast, Breast
Motivation: HER2-low breast cancer patients may benefit from newly devised antibody-drug conjugates. However, the challenge lies in accurately identifying HER2-low status through non-invasive imaging techniques.
Goal(s): Investigating the value of ultra-fast DISCO DCE for differentiating HER2-zero, HER2-low, and HER2-oe BC.
Approach: 39 HER2-zero, 78 HER2-low, and 56 HER2-oe BC patients were involved. Quantitative kinetic parameters were calculated from DISCO DCE, including MS, BAT, Ktrans, Kep, Ve, IAUGC, and CER.
Results: Kep and CER were independent factors to distinguish HER2-zero from HER2-low. MS and BAT were independent factors to discriminate HER2-zero from HER2-oe. BAT, Ve, and IAUGC were independent factors to differentiate HER2-low from HER2-oe.
Impact: Our results suggested ultra-fast DISCO DCE derived quantitative kinetic parameters can serve as non-invasive biomarkers for identifying HER2-zero, HER2-low, and HER2-oe. The application of DISCO DCE would be beneficial for guiding treatment selection and monitoring HER2 status change during treatment.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords