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Abstract #1071

Early Treatment Response Evaluation Using 31P MRSI at 7T in Liver Metastases of 4 Patients With Gastroesophageal Cancer Given Systemic Treatment

Sebastiaan Siegerink1,2, Bobby Runderkamp3, Adrianus J. Bakermans3, Mark Gosselink4, Nadia Haj Mohammad4, Aart J. Nederveen3, Dennis Klomp4, Hanneke W.M. van Laarhoven1,2, and Jeanine J. Prompers4,5
1Medical Oncology, Amsterdam UMC, Amsterdam, Netherlands, 2Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands, 3Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, 4Imaging and Oncology, UMC Utrecht, Utrecht, Netherlands, 5Human Biology and Imaging, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht UMC+, Maastricht, Netherlands

Synopsis

Keywords: Spectroscopy, Treatment Response, Gastroesophageal Cancer, Metastases

Motivation: Patients with metastatic gastroesophageal cancer(GEC) have a poor prognosis. Timely treatment response evaluation could prevent continuation of ineffective treatment and improve quality of life.

Goal(s): To compare treatment-induced changes in 31P MRSI PME/PDE ratios in liver metastases of GEC between baseline and after 2 weeks of treatment with CT-based response evaluation at 9 weeks.

Approach: Four patients with liver metastases of GEC who received first-line systemic therapy underwent 31P MRSI at 7 Tesla at baseline and after 2 weeks of treatment.

Results: Poor response at 9 weeks was associated with increased PME/PDE after 2 weeks, whereas good response was associated with decreased PME/PDE.

Impact: This study shows promising results of 31P MRSI to evaluate systemic therapy response after only 2 weeks in patients with liver metastases of gastroesophageal cancer.

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Abstract

Keywords