Abstract #1073

Prospective Investigation of the Value of Arterial Spin Labeling for Evaluating Bladder Cancer

Erjia Guo¹, Gumuyang Zhang¹, Li Chen¹, Jinxia Zhu², Bernd Kuehn³, Jiahui Zhang¹, Xiaoxiao Zhang¹, Xin Bai¹, Qianyu Peng¹, Yongfei Wu¹, Zhengyu Jin¹, and Hao Sun¹

¹Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China, ²MR Research Collaboration, Siemens Healthineers, Beijing, China, Beijing, China, ³MR Application Predevelopment, Siemens Healthineers AG, Forchheim, Germany, Forchheim, Germany

Synopsis

Keywords: Urogenital, Bladder, ASL

Motivation: Current bladder cancer (BCa) evaluation techniques require contrast agent, which is contraindicated in some patients.

Goal(s): We aimed to assess the potential value of arterial spin labeling (ASL) for evaluating BCa.

Approach: We conducted ASL scans of patients with BCa and obtained corresponding perfusion values (bladder blood flow [BBF]) of the bladder lesions. We collected pathological and immunohistochemical information, dynamic contrast-enhanced quantitative parameters, and K^trans values.

Results: BBF and K^trans were moderately positively correlated. BBF values for high-grade urothelial carcinoma, muscle invasion and Ki-67 >25% were higher than those for low-grade urothelial carcinoma, non-muscle invasion and Ki-67 ≤25% (P<0.05).

Impact: Non-invasive and quantitative arterial spin labeling is a valuable technique for evaluating bladder cancer because it enables quantifying tumor perfusion and offers insights into the physiological and pathological processes.

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