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Abstract #1076

Towards Free-Breathing Nodal Staging of Upper Abdominal Cancers: MRI-Visible Nodal Size Distributions and Uptake of USPIO Nanoparticles

Tom WJ Scheenen1, Marnix Maas1, Kai Tobias Block2, Rik van den Elshout1, Andor Veltien1, Ewoud Smit1, John Hermans1, and Ivo Maatman1
1Medical Imaging, Radboud university medical centre, Nijmegen, Netherlands, 2Radiology, NYU Langone Health, New York, NY, United States

Synopsis

Keywords: Cancer, Motion Correction

Motivation: Respiratory motion complicates the detection of abdominal LNs, which are crucial to detect with USPIO-enhanced MRI for nodal staging of upper abdominal cancers.

Goal(s): Evaluate if a free-breathing radial stack-of-stars acquisition can match or outperform Cartesian reference scans for the depiction of small abdominal lymph nodes.

Approach: Five volunteers with USPIO and 20 patients without USPIO were scanned using radial stack-of-stars, Cartesian dual-echo, and fat-saturated (FS) Cartesian multi-echo sequences for fat/water imaging and clip_image002.gif"> estimation.

Results: Radial imaging improved image quality over the Cartesian reference standard, identifying substantially more LNs.

Impact: Our method effectively depicts LNs and visualize their USPIO uptake in the upper abdomen. All relevant parameters are obtained from a single free-breathing radial acquisition, yielding higher image quality and more sensitive detection of small lymph nodes.

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Keywords