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Abstract #1078

Phosphorus Metabolite Profiling of Hepatocellular Carcinoma Using 31P-MRS: A Comparative Study with Surrounding Liver Tissue

Jingzhe Li1,2, Huimin Lin1, Fuhua Yan1,2, and Peng Wu3
1Ruijin Hospital, Shanghai, China, 2Faculty of Medical Imaging Technology, College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 3Philips Healthcare, Shanghai, China

Synopsis

Keywords: Liver, Liver, phosphorus magnetic resonance spectroscopy

Motivation: Hepatocellular carcinoma (HCC) is associated with metabolic changes in phosphorus metabolites, which may reveal its biochemical mechanisms.

Goal(s): To compare metabolic differences between HCC lesions and surrounding liver tissue using 31P-MRS.

Approach: 47 patients with HCC underwent 31P-MRS to measure phosphoethanolamine (PE), phosphocholine (PC), inorganic phosphate (Pi), and ATP derivatives. Ratios of PME/PDE and PE/PME were compared between HCC lesions and surrounding liver tissue.

Results: HCC lesions showed higher PME/PDE and PE/PME ratios, indicating altered membrane turnover and supporting tumor cell membrane reorganization.

Impact: These metabolic shifts in HCC lesions may aid in diagnosis and monitoring of liver cancer.

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