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Abstract #1091

Reproducibility of advanced MR measures across all 3 major scanner vendors in a longitudinal 5-site multiple sclerosis study

Irene M Vavasour1, Anthony Traboulsee2, Jiwon Oh3, Roger Tam4, and Shannon Kolind1,2,5
1Radiology, University of British Columbia, Vancouver, BC, Canada, 2Medicine, University of British Columbia, Vancouver, BC, Canada, 3Medicine, University of Toronto, Toronto, ON, Canada, 4Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada, 5Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada

Synopsis

Keywords: Quantitative Imaging, Quantitative Imaging

Motivation: Advanced brain and spinal cord MRI is being collected in the Canadian prospective cohort study to understand progression in multiple sclerosis (CanProCo). Reproducibility was investigated in healthy controls.

Goal(s): Determine reproducibility of brain volumetrics, myelin water fraction, magnetisation transfer ratio, diffusion tensor imaging metrics and spinal cord area across sites.

Approach: 52 healthy controls were scanned at year 0 and 1 at a 3T site (2 Siemens, 2 Philips, 1 GE). Reproducibility was assessed using intraclass correlation coefficients, Bland-Altman plots and coefficients of variation.

Results: Variability in most MR metrics was similar between sites although values themselves differed for a few metrics.

Impact: CanProCo is a Canada-wide study collecting advanced brain and spinal cord MRI. Reproducibility of healthy control data was assessed to enable interpretation of longitudinal multi-site multiple sclerosis data. Variability in most MR metrics over 1 year was similar between sites.

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Keywords