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Abstract #1095

QSM can distinguish hemosiderin from calcification in carotid atherosclerotic plaque: an ex vivo MRI study of carotid endarterectomy specimens

Hideki Ishimaru1, Ayano Ishiyama1, Shinji Okano2, Minoru Morikawa3, Tomoki Nakano1, Chika Somagawa1, Yutaro Tasaki3, Syuhei Miyazaki1, and Ryo Toya1
1Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 2Pathology, Nagasaki University Hospital, Nagasaki, Japan, 3Radiology, Nagasaki University Hospital, Nagasaki, Japan

Synopsis

Keywords: Quantitative Imaging, Quantitative Susceptibility mapping

Motivation: In plaque MRI, low signal intensity on all contrast weightings has been diagnosed as calcification; however, it is possible that some hemosiderin deposits have been misdiagnosed as calcification. As QSM clearly distinguishes between paramagnetic and diamagnetic materials, it could be useful in distinguishing hemosiderin from calcifications.

Goal(s): To demonstrate that QSM is useful for distinguishing hemosiderin from calcification in plaques.

Approach: 24 carotid endarterectomy specimens were examined ex vivo using 3T MRI. We compared the signal intensities on conventional MRI and QSM with reference to pathology.

Results: Hemosiderin and calcification, which had similar signals on conventional MRI contrast, were clearly distinguished using QSM.

Impact: By using QSM, we can avoid misdiagnosing hemosiderin in atherosclerotic plaque as calcification.

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