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Abstract #1100

MARVEL MRF for Contrast-free Blood Volume, Microvascular Properties, and Relaxometry Mapping: Initial Tests in Volunteers and Stroke Patients

Antoine Barrier1, Lila Cunge1, Thomas Coudert1, Aurélien Delphin2, Loïc Legris3, Geoffroy Oudoumanessah1,4,5, Laurent Lamalle2, Florence Forbes4, Mariya Doneva6, Benjamin Lemasson1, Emmanuel L. Barbier1, and Thomas Christen1
1Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, GIN, Grenoble, France, 2Univ. Grenoble Alpes, Inserm, US17, CNRS, UAR 3552, CHU Grenoble Alpes, IRMaGe, Grenoble, France, 3Univ. Grenoble Alpes, Inserm, U1216, Stroke Unit, Department of Neurology, CHU Grenoble Alpes, Grenoble Institut Neurosciences, Grenoble, France, 4Univ. Grenoble Alpes, Inria, CNRS, Grenoble INP, LJK, Grenoble, France, 5Univ. Lyon, CNRS, Inserm, INSA Lyon, UCBL, CREATIS, UMR5220, U1294, F‐69621, Villeurbanne, France, 6Philips Innovative Technologies, Hamburg, Germany

Synopsis

Keywords: MR Fingerprinting, MR Fingerprinting, MRF, vascular, AI, LSTM, Fingerprinting, blood volume, CBV

Motivation: An MRF method has been proposed to simultaneously estimate microvascular properties and relaxometry without contrast agent injection. A bidirectional LSTM network has been used to offer ultra-fast MRF reconstruction times.

Goal(s): To test the combined MARVEL MRF model in volunteers and patients.

Approach: Data were acquired in 9 volunteers. Fully sampled Cartesian, Compressed SENSE, and three spiral undersampling schemes were compared to standard matching. 2 follow-up stroke patients were included.

Results: MARVEL produced high-quality maps in seconds from high-SNR acquisitions and an interesting robustness to undersampling schemes. In stroke patients, reconstructed maps highlighted lesions but suffered from motion artifacts.

Impact: MARVEL MRF produces high-quality relaxation maps and non-contrast microvascular estimates in seconds from high SNR acquisitions and an interesting robustness to undersampling schemes. Once corrected for motion and shim artifacts, MARVEL could be used for the management of stroke patients.

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Keywords