Abstract #1109

Mesoscale Myelin Water Fraction Mapping at 3T with Self-navigated Motion Correction

Shohei Fujita^1,2,3,4, Yohan Jun^1,2, Antoine Delattre-Klauser^5,6,7, Gian Franco Piredda⁵, Tom Hilbert^5,6,7, Cemre Ariyurek^2,8, Onur Afacan^2,8, Borjan Gagoski^2,9, and Berkin Bilgic^1,2,10

¹Athinoula A. Martinos Center for Biomedical Imaging Center, Boston, MA, United States, ²Department of Radiology, Harvard Medical School, Boston, MA, United States, ³Department of Radiology, The University of Tokyo, Tokyo, Japan, ⁴Department of Radiology, Juntendo University, Tokyo, Japan, ⁵Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁶Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁷LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁸Computational Radiology Laboratory, Boston Children's Hospital, Boston, MA, United States, ⁹Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children’s Hospital, Boston, MA, United States, ¹⁰Harvard/MIT Health Sciences and Technology, Cambridge, MA, United States

Synopsis

Keywords: Motion Correction, Nervous system, Biomarkers; Quantitativ e Imaging

Motivation: Relaxometry and myelin water quantification at high resolution is crucial for understanding neurodevelopment. Deployment of these encoding-intensive techniques at mesoscale resolutions is hampered by motion and prolonged scans.

Goal(s): To develop a T₁, T₂, and myelin water fraction (MWF) mapping technique at mesoscale resolution with self-navigated motion correction at 3T.

Approach: 3D-QALAS sequence was extended to include a short-TE T₂-preparation module to boost sensitivity to myelin, and motion information extracted from a tailored sampling trajectory from each TR is then incorporated into the reconstruction’s forward model.

Results: An 8.1min motion-robust acquisition at 790um resolution was demonstrated with high fidelity at 3T.

Impact: We propose MWF-QALAS for simultaneous mapping of T₁, T₂, and myelin water fraction (MWF) with self-navigated motion correction for high-fidelity multi-parametric mapping on a 3T system at the mesoscale resolution of 790 um isotropic within 8.1 minutes.

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