Abstract #1125

Structural-functional coupling subtypes of major depressive disorder and their associations with genetic and neurotransmitter profiles

Huaijin Gao¹, Rui Qian¹, Yihan Ma¹, Baorong Gu¹, Tao Jin¹, Dan Wu^1,2, and Zhiyong Zhao²

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ²Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China

Synopsis

Keywords: Psychiatric Disorders, Brain Connectivity, Structural-functional coupling;Gene;Neurotransmitter;Major Depressive Disorder

Motivation: The neurobiological underpinning of heterogeneity in structural-functional coupling (SFC) remains unclear in major depressive disorder (MDD).

Goal(s): This study aims to explore subtypes of MDD based on SFC alteration and investigate their differences in clinical symptoms and the molecular basis of SFC alterations.

Approach: We calculated SFC derived from resting-state fMRI and T1-weighted images, identified MDD subtypes based on its alterations, and correlated SFC alterations with clinical assessments, genes and neurotransmitters.

Results: Two MDD subtypes characterized by increased and decreased SFC were identified in present study, respectively. They demonstrated differences in depressive symptoms and exhibited different molecular basis for their SFC alterations.

Impact: Our study identified two neurophysiological subtypes of MDD, characterized by unique SFC alteration patterns, along with specific associations with genetic and neurotransmitter profiles. These subtypes may offer promising implications for personalized diagnosis and targeted treatment of MDD.

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