Keywords: Quantitative Imaging, Metabolism
Motivation: While the neurometabolic consequences of obstructive sleep apnea (OSA) are thought to play a role in downstream risk for various disorders, quantifying these changes during natural sleep remains a scientific challenge.
Goal(s): We aim to validate a custom MRI sequence for detecting neurometabolism and upper airway architecture during volitional apneas.
Approach: During scanning, awake healthy volunteers were asked to perform breath holds and swallowing apneas.
Results: Both breath-hold and swallowing model apneas increased CBF and SVO2 resulting in increased CMRO2, but only swallowing apneas were associated with an effective closure of the upper airway.
Impact: Identifying specific changes in neurometabolism and upper-airway architecture with an experimental paradigm validates the proposed approach before applications in a more challenging naturalistic observation. Experiments in healthy subjects also helps contextualize the magnitude of changes noted in natural observations.
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