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Abstract #1140

Novel MRI Pulse Sequence to Image Upper Airway Anatomy and Measure Changes in Neurometabolism During Volitional Model Apneas

Jeffrey Brandon Dennison1, Michael Langham1, and Felix Wehrli1
1Radiology, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Quantitative Imaging, Metabolism

Motivation: While the neurometabolic consequences of obstructive sleep apnea (OSA) are thought to play a role in downstream risk for various disorders, quantifying these changes during natural sleep remains a scientific challenge.

Goal(s): We aim to validate a custom MRI sequence for detecting neurometabolism and upper airway architecture during volitional apneas.

Approach: During scanning, awake healthy volunteers were asked to perform breath holds and swallowing apneas.

Results: Both breath-hold and swallowing model apneas increased CBF and SVO2 resulting in increased CMRO2, but only swallowing apneas were associated with an effective closure of the upper airway.

Impact: Identifying specific changes in neurometabolism and upper-airway architecture with an experimental paradigm validates the proposed approach before applications in a more challenging naturalistic observation. Experiments in healthy subjects also helps contextualize the magnitude of changes noted in natural observations.

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