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Abstract #1143

Accelerated DESPOT1 with variable parameters for 3D T1 brain mapping

Ronal Coronado1,2, Cecilia Besa2,3, René Botnar1,2,4,5, Pablo Irarrazaval5,6, and Claudia Prieto2,7
1School of Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 2Millenium Institute for Intelligent Healthcare Engineering, Santiago, Chile, 3Departamento de Radiologia-Universidad Católica de Chile, Santiago, Chile, 4School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, 5Institute for Biological and Medical Engineering, Santiago, Chile, 6Electrical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 7Pontificia Universidad Catolica de Chile, Santiago, Chile

Synopsis

Keywords: Data Acquisition, Quantitative Imaging, DESPOT1, SPGR, T1 Brain mapping, dictionary-based reconstruction

Motivation: Driven Equilibrium Single Pulse Observation of T1 (DESPOT1) is a reliable technique for 3D T1 brain mapping based on a spoiled gradient echo sequence. However, its fixed repetition-time (TR) and bandwidth (BW) limit flexibility, resulting in long scan times.

Goal(s): To accelerate DESPOT1 by introducing variable TRs, flip angles (FAs), and BWs, combined with a dictionary-based reconstruction approach.

Approach: Our method involves using a DESPOT1 acquisition with optimized combinations of TRs, BWs, and FAs, coupled with dictionary-based reconstruction to achieve faster 3D-brain T1 mapping.

Results: Results demonstrate an approximately 40% reduction in scan time, allowing faster 3D T1 brain mapping while maintaining accuracy.

Impact: By using variable TRs, FAs, and BWs with dictionary-based reconstruction, this research improves DESPOT1 adaptability and speed, reducing scan time by 40% for 3D in-vivo T1 brain mapping and promising broader applications in research and clinical settings.

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Keywords