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Abstract #1145

Selective and targeted imaging for pancreatic cancer in a mouse model: structured polyethylene glycol as a specific MR molecular imaging agent

Scott D. Swanson1, Noah Nelson2, Thomas Hopkins3, and Andew Hopkins3
1Department of Radiology, University of Michigan, Ann Arbor, MI, United States, 2Department of Pathology, University of Michigan, Ann Arbor, MI, United States, 3Kuva Labs Inc., Houston, TX, United States

Synopsis

Keywords: Small Animals, Molecular Imaging, Pancreatic Cancer Detection

Motivation: Demonstrate a Gd-free, MR molecular imaging agent selective to solid cancers. Deliver an MR imaging technique for the detection and diagnosis of solid cancers.

Goal(s): Show that structured PEG nanopolymers (sPEG), can be delivered to and used to monitor pancreatic cancer.

Approach: Diffusion-weighted, T2-weighted, single-shot FSE with 64 echoes was used to suppress water and selectively image sPEG in phantoms, in vivo in matrigel flank injections, and in orthotopic pancreatic cancer in C57BL/6 mice.

Results: We demonstrate that sPEG signal is linear with concentration, can be selective imaged in vivo, and, in concert with iRGD, can be used to image pancreatic cancer.

Impact: The delivery and MRI of the sPEG nanopolymers demonstrate a clear path to a new imaging paradigm – yielding PET-like images of sPEG and providing oncologists and radiologists with a new tool to quickly detect and diagnose solid cancers.

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