Keywords: Small Animals, Molecular Imaging, Pancreatic Cancer Detection
Motivation: Demonstrate a Gd-free, MR molecular imaging agent selective to solid cancers. Deliver an MR imaging technique for the detection and diagnosis of solid cancers.
Goal(s): Show that structured PEG nanopolymers (sPEG), can be delivered to and used to monitor pancreatic cancer.
Approach: Diffusion-weighted, T2-weighted, single-shot FSE with 64 echoes was used to suppress water and selectively image sPEG in phantoms, in vivo in matrigel flank injections, and in orthotopic pancreatic cancer in C57BL/6 mice.
Results: We demonstrate that sPEG signal is linear with concentration, can be selective imaged in vivo, and, in concert with iRGD, can be used to image pancreatic cancer.
Impact: The delivery and MRI of the sPEG nanopolymers demonstrate a clear path to a new imaging paradigm – yielding PET-like images of sPEG and providing oncologists and radiologists with a new tool to quickly detect and diagnose solid cancers.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords