Abstract #1154

Accelerated T1ρ and T2 High Resolution Imaging: a Multi-vendor Multi-site study

Zhiyuan Zhang^1,2,3, Jeehun Kim^1,2, Ruiying Liu⁴, Richard Latery^1,2, Carl S Winalski^1,2,5, Mingrui Yang^1,2, Jing Liu⁶, Thomas M Link⁶, Qi Peng⁷, Michael A Samaan⁸, Peter Hardy⁹, Leslie Ying^4,10, and Xiaojuan Li^1,2,5

¹Program of Advanced Musculoskeletal Imaging (PAMI)), Cleveland Clinic, Cleveland, OH, United States, ²Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States, ³Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ⁴Department of Electrical Engineering, University at Buffalo, Buffalo, NY, United States, ⁵Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, ⁶Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ⁷Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, United States, ⁸Department of Kinesiology & Health Promotion, University of Kentucky, Lexington, KY, United States, ⁹Department of Radiology, University of Kentucky, Lexington, KY, United States, ¹⁰Department of Biomedical Engineering, University at Buffalo, Buffalo, NY, United States

Synopsis

Keywords: Cartilage, Cartilage

Motivation: High-resolution T1ρ and T2 imaging techniques offer improved capabilities for detecting early cartilage degeneration in osteoarthritis. However, these techniques require long acquisition time.

Goal(s): To develop and evaluate novel accelerated high-resolution T1ρ and T2 imaging techniques in a multi-vendor multi-site setting.

Approach: 33 local volunteers and 2 traveling volunteers were scanned at 3T for T1ρ and T2 imaging using both reference and accelerated sequences with compressed sensing. Scans were performed at standard(0.44x0.88x4mm³) and high(0.37x0.73x1.6mm³) resolutions across four sites with MR platforms from three vendors.

Results: Coefficients of variation(CVs) between reference and accelerated maps were <4.5%. Scan-rescan CVs were <3%. Inter-site CVs were <4%.

Impact: We demonstrated high-resolution fast cartilage relaxometry imaging is reliable and reproducible, with excellent agreement between reference and accelerated imaging, excellent scan-rescan repeatability, and consistency across sites and vendors. Such techniques will greatly facilitate the clinical translation of quantitative knee imaging.

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