Keywords: Cartilage, MSK, qMT, Cartilage, osteoarthritis
Motivation: Quantitative magnetization transfer (qMT) provides biomarkers to assess articular cartilage extracellular matrix. Currently, qMT techniques are limited to small cartilage region coverage.
Goal(s): Characterize the knee cartilage extracellular matrix using novel qMT imaging technique BTS (Bloch-Siegert and magnetization Transfer Simultaneously).
Approach: A new BTS protocol was implemented to image the knee and investigate remodeling of the BTS model to estimate full set of bias-free T1, f, kF and additional T2R for characterizing the whole knee cartilage extracellular matrix.
Results: Spatial variation reflecting the regional dependence of qMT parameters and depth dependence between the deep and superficial layers of cartilage was observed.
Impact: BTS showed spatial variation and regional features of qMT parameters in a healthy model, presenting great potential in providing 3D relaxometry and qMT imaging biomarkers to characterize whole knee cartilage extracellular matrix, which requires further investigation using groupwise analysis.
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