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Abstract #1164

MRE-Assessed Hepatic Stiffness Gradient Distinguishes Congestive Hepatopathy from Non-congestive Chronic Liver Disease

Jiahui Li1, Peng Xu1, Hao Wu1, Alina M. Allen2, Kevin J. Glaser1, Armando Manduca1, Moira B. Hilscher2, Doug A. Simonetto2, Vijay H. Shah2, Richard L. Ehman1, Sudhakar K. Venkatesh1, and Meng Yin1
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States

Synopsis

Keywords: Liver, Elastography

Motivation: Congestion and consequent fibrosis lead to increased liver stiffness in Fontan-associated liver disease (FALD). Stiffness gradient (SG) may distinguish congestive hepatopathy from other chronic liver diseases.

Goal(s): To evaluate the repeatability of MRE-assessed hepatic SG and evaluate its ability to differentiate congestive (FALD) and noncongestive (MASLD) hepatopathy.

Approach: Inter-reader repeatability of SG was assessed in 80 exams by ICC and Bland-Altman analysis. The group difference of SG was compared between 38 FALD and 19 MASLD patients matched by their mean liver stiffness.

Results: SG has excellent repeatability (ICC=0.82, Bias=-0.0019kPa/mm). FALD has a significantly steeper SG than MASLD (-0.036 [-0.050,-0.028] vs. -0.018 [-0.027,-0.003]kPa/mm, p<0.001).

Impact: FALD patients exhibit more pronounced liver stiffness gradients from the liver capsule to IVC compared to MASLD patients with similar mean liver stiffness. MRE-assessed stiffness gradient may be a promising parameter for diagnosing and monitoring congestive liver diseases.

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