Abstract #1168

Chronic Liver Disease: Comparison of 4D Flow to 2D Flow MRI in the Portal Vein in Healthy Volunteers and Patients

Shan Cai^1,2, Wolf Claus Bartholomä^2,3, Nils Dahlström^2,3, Jens Tellman¹, Stergios Kechagias⁴, Patrik Nasr⁴, Mattias Ekstedt⁴, Marie Byenfeldt^2,3, Johan Kihlberg^2,3, and Peter Lundberg^1,2

¹Department of Radiation Physics, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden, ²Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden, ³Department of Radiology, and Department of and Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden, ⁴Department of Gastroenterology and Hepatology, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden

Synopsis

Keywords: Liver, Diagnosis/Prediction, Chronic liver disease, cirrhosis, MRE, portal hemodynamics

Motivation: Flow parameters derived from 4D flow MRI may help detect cirrhosis and portal hypertension, but hemodynamic changes in fibrosis progression remains unclear.

Goal(s): Compare 4D with standard 2D flow MRI for assessing portal hemodynamic changes in chronic liver disease (CLD) patients compared with healthy volunteers, and investigate correlations with MRE-derived liver stiffness.

Approach: 18 healthy controls and 55 CLD patients underwent MRI at 3 T.

Results: 4D flow MRI showed good consistency with 2D flow MRI but with a tendency of underestimation. Both flow modalities distinguished CLD patients from controls. Velocity was negatively correlated with liver stiffness in significant fibrosis and above.

Impact: 4D flow MRI could serve as an alternative to 2D flow MRI for quantifying portal hemodynamics and may reflect vascular changes associated with fibrosis progression.

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