Keywords: Liver, Liver, Hepatocellular Carcinoma (HCC); LI-RADS; Contrast-Enhanced Magnetic Resonance Imaging (CE-MRI); Diagnostic Criteria; Alpha-Fetoproteins
Motivation: Current diagnostic criteria for subcentimeter HCC lack sufficient sensitivity, leading to delayed detection and poorer outcomes.
Goal(s): To evaluate the diagnostic performance of LI-RADS v2018 and r-LI-RADS for subcentimeter HCC and to develop a new criterion integrating serum AFP levels and gadolinium-based CE-MRI features.
Approach: Retrospective study of 179 patients with 92 pathologically confirmed HCC and 87 non-HCC lesions (<1 cm), using conventional gadolinium contrast. Optimal AFP threshold and logistic regression identified predictors.
Results: New criterion with ≥3 positive factors (AFP > 12.15 ng/mL, non-peripheral arterial phase enhancement, diffusion restriction, fat deposition, enhancing capsule) achieved 78.3% sensitivity, surpassing LR-4, r-LR-5/4, and r-LR-4.
Impact: Enhances diagnostic sensitivity for subcentimeter HCC, improving early detection and patient outcomes.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords