Keywords: Digestive, Digestive
Motivation: CD is incurable, often requiring surgery; multiomics factors' roles in inflammation and MRE need clarification.
Goal(s): Identify inflammation-related multiomics factors and their interactions with magnetic resonance enterography (MRE) to provide novel targets for CD management.
Approach: This study analyzed 425 CD patients and 42 healthy controls using MRE, ileocolonoscopy, 16S rRNA analysis, and targeted metabolomics.
Results: Ruminococcus species increased in CD; Pseudomonas and Staphylococcus linked to severe inflammation. Key metabolites influence intestinal changes and inflammation progression.
Impact: Findings highlight dynamic alterations in gut microbiota and metabolites, offering insights for improved inflammation management in CD.
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