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Abstract #1172

Gut microbiome and metabolite changes are linked to intestinal inflammation progression and MR enterography abnormalities in Crohn's disease

Xiaoyu Hua1 and Ruonan Zhang2
1Medical Imaging Centre, The First Affiliated Hospital, Jinan University, guangzhou, China, 2Radiology, The First Affiliated Hospital of Sun Yat-Sen University, guangzhou, China

Synopsis

Keywords: Digestive, Digestive

Motivation: CD is incurable, often requiring surgery; multiomics factors' roles in inflammation and MRE need clarification.

Goal(s): Identify inflammation-related multiomics factors and their interactions with magnetic resonance enterography (MRE) to provide novel targets for CD management.

Approach: This study analyzed 425 CD patients and 42 healthy controls using MRE, ileocolonoscopy, 16S rRNA analysis, and targeted metabolomics.

Results: Ruminococcus species increased in CD; Pseudomonas and Staphylococcus linked to severe inflammation. Key metabolites influence intestinal changes and inflammation progression.

Impact: Findings highlight dynamic alterations in gut microbiota and metabolites, offering insights for improved inflammation management in CD.

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