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Abstract #1181

Towards time-efficient sodium and proton MRI at 7T

Menglu Wu1,2, Jon Cleary1,2,3, Philippa Bridgen2,4, Pierluigi Di Cio2,4, Sarah McElroy1,5, Samuel Rot6, Yasmin Blunck7,8, David W Carmichael1,2, and Özlem Ipek1,2
1Imaging physics and engineering research department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2London Collaborative Ultra high field System (LoCUS), London, United Kingdom, 3Department of Radiology, Guy’s and St. Thomas’ NHS Foundation Trust, London, United Kingdom, 4Guys and St Thomas’ NHS Foundation Trust, Kings College London, London, United Kingdom, 5MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom, 6NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, UCL, London, United Kingdom, 7Department of Biomedical Engineering & Graeme Clark Institute, The University of Melbourne, Victoria, Australia, 8Melbourne Brain Centre Imaging Unit, The University of Melbourne, Victoria, Australia

Synopsis

Keywords: RF Arrays & Systems, Non-Proton

Motivation: Sodium(²³Na) imaging may provide new assessments of neurological and physiological function, together with complimentary proton(¹H) MRI. However, current approaches lack efficient examination workflow.

Goal(s): To develop a coil capable of both ¹H/²³Na imaging at 7T for improved workflow, with validated SAR, and high image quality.

Approach: We designed a 16-channel ²³Na-loop/¹H-dipole array, validated safety through EM simulations and phantom experiments, and piloted in-vivo imaging compared to commercial alternatives.

Results: Our array demonstrated comparable ²³Na image quality to a commercial coil, while enabling ¹H imaging with reduced RF power constraints. This pilot suggests simplified workflow for sequential ¹H/²³Na imaging without patient repositioning is possible.

Impact: Pilot results demonstrate that integrated multichannel ²³Na/¹H transmit-receive RF coil design at 7T enables sufficient image quality without patient repositioning, streamlining workflow and reducing co-registration demands, paving the way for time-efficient multinuclear imaging in clinical applications.

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Keywords