Abstract #1217

Associations of lenticulostriate artery geometry and hemodynamics with age, vascular risks, and cognitive decline: A high-resolution 7T study.

Jianing Tang^1,2, Tarin T Tanji³, Michael Anukwu⁴, Tianrui Zhao^1,2, Elizabeth Joe⁵, Helena Chui⁵, and Lirong Yan^1,2

¹Department of Radiology, Northwestern University, Chicago, IL, United States, ²Department of Biomedical Engineering, Northwestern University, Chicago, IL, United States, ³Rush Medical College, Chicago, IL, United States, ⁴Meharry Medical College, Nashville, TN, United States, ⁵Department of Neurology, University of Southern California, Los Angeles, CA, United States

Synopsis

Keywords: Blood Vessels, Blood vessels

Motivation: LSA plays a crucial role in the pathology of small vessel disease. Directly assessing LSA pulsatility and geometry may provide valuable insights into pathology of SVD.

Goal(s): To assess LSA pulsatility and geometry using 7T high-resolution MRI techniques in elderly adults and investigate their association with age, vascular risks, and cognitive impairment.

Approach: Retrospectively gated dual-VENC PC-MRI and 3D high-resolution TOF were performed on 7T to assess LSA pulsatility and geometry in elderly adults.

Results: Our results showed that increased LSA pulsatility and reduced LSA geometric features (LSA stems, branches, length) were correlated with aging, vascular risk factors, and cognitive impairment.

Impact: 7T high-resolution MRI including dual-VENC PC-MRI and 3D TOF provide comprehensive assessment of LSA geometry and flow dynamics, offering a class of sensitive imaging biomarkers for small vessel disease and cognitive impairment, and providing valuable insights into SVD pathology.

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