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Abstract #1220

Cerebrovascular Reactivity Response Times Following Revascularization Surgery in Patients with Moyamoya

Wesley Thomas Richerson1, Alex Bhogal2, Caleb Han3, Maria Garza3, Alex Song3, Matthew Fusco4, Rohan Thomas Chitale4, Lori Jordan5, and Manus Donahue3
1Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, 2Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 3Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, 4Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, United States, 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, United States

Synopsis

Keywords: Stroke, Stroke, Cerebrovascular Reactivity, BOLD-CVR Modeling

Motivation: Blood-oxygenation-level-dependent cerebrovascular reactivity (BOLD-CVR) is increasingly used to assay impairment in moyamoya disease, however BOLD-CVR response to surgery has not been fully characterized with a fixed inspiration stimulus.

Goal(s): To fully characterize the temporal BOLD-CVR response to revascularization surgery in MMD patients and test the relative sensitivities of a time-shift regression analysis against an exponential model of BOLD-CVR to revascularization surgical changes.

Approach: Time-shift regression and exponential model analysis were applied in 33 brain hemispheres of moyamoya participants before and after revascularization surgery.

Results: With a fixed-hypercapnic stimulus, the temporal BOLD-CVR response was highly sensitive to changes due to revascularization surgery.

Impact: Cerebrovascular reactivity (CVR) response times in both time-shifted and exponential models were significantly decreased in response to revascularization surgery in moyamoya patients, motivating the utilization of CVR response times as a biomarker to evaluate treatment in moyamoya disease.

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Keywords