Keywords: Blood Vessels, DSC & DCE Perfusion
Motivation: To precisely quantify cerebrovascular properties in brain tissue.
Goal(s): To rigorously test the reliability and repeatability of a DSC acquisition and processing model at 3T and 7T.
Approach: Twice repeated 2Hz multiband DSC experiments at 3T and 7T in 14 young and aged subjects are used to quantify voxel-wise blood flow, mean capillary transit time, and bolus arrival times across the brain; repeatability over runs and reliability over subjects are assessed for multiple metrics.
Results: The acquisition and automated processing methods detailed herein yield repeatable and reliable metrics of the cerebrovascular system. Current work includes testing under neurological disease states.
Impact: This high temporal and spatial resolution method is easily accessible and precludes the necessity of using commonly derived "relative" metrics; absolute metrics make effortless the translation and comparison of derived cerebrovascular qualities across diseases, studies, individuals, and the brain.
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