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Abstract #1222

Reliable and repeatable derived cerebrovascular metrics using 2Hz DSC MRI at 3T and 7T

Daniel L Schwartz1,2, Eric Baker1, Brendan Moloney1, Xin Li1, Olivia Huerta1, Frederic Lesage3, Andreas Linninger4, and WIlliam D. Rooney1,2
1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 2Neurology, Oregon Health & Science University, Portland, OR, United States, 3Electrical Engineering, Polytechnique Montreal, Montréal, QC, Canada, 4Bioengineering, University of Illinois at Chicago, Chicago, IL, United States

Synopsis

Keywords: Blood Vessels, DSC & DCE Perfusion

Motivation: To precisely quantify cerebrovascular properties in brain tissue.

Goal(s): To rigorously test the reliability and repeatability of a DSC acquisition and processing model at 3T and 7T.

Approach: Twice repeated 2Hz multiband DSC experiments at 3T and 7T in 14 young and aged subjects are used to quantify voxel-wise blood flow, mean capillary transit time, and bolus arrival times across the brain; repeatability over runs and reliability over subjects are assessed for multiple metrics.

Results: The acquisition and automated processing methods detailed herein yield repeatable and reliable metrics of the cerebrovascular system. Current work includes testing under neurological disease states.

Impact: This high temporal and spatial resolution method is easily accessible and precludes the necessity of using commonly derived "relative" metrics; absolute metrics make effortless the translation and comparison of derived cerebrovascular qualities across diseases, studies, individuals, and the brain.

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