Abstract #1224

Whole-cerebrum three-dimensional pseudo-continuous arterial spin labeling at 5T: reproducibility and preliminary application in moyamoya

Zhonghui Li¹, Xiaoyuan Fan¹, Guangsong Han², Hui You¹, Jun Ni², Mingli Li³, and Feng Feng¹

¹Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China, ²Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Beijing, China, ³Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Beijing, China

Synopsis

Keywords: Blood Vessels, Brain

Motivation: The ultra-high field of 5T MRI system may be a balanced choice for SNR and inversion efficiency in PCASL imaging.

Goal(s): Achieve whole-cerebrum PCASL imaging at ultra-high field 5T MRI system, assess the reproducibility and preliminarily explore its clinical application in moyamoya disease/syndrome.

Approach: Twenty healthy volunteers were performed with single-delay and multi-delay PCASL sequences twice for reproducibility analysis. Twenty-six patients with moyamoya disease/syndrome were underwent multi-delay PCASL.

Results: Uncorrected CBF, corrected CBF and ATT showed excellent reliability in all regions especially in regions with heterogeneous transit time. In patients with moyamoya disease/syndrome, those with higher ACA or MCA scores exhibited lower cCBF.

Impact: Whole-Cerebrum PCASL imaging at 5T ultra-high field offers a promising tool in the assessment of hemodynamic conditions in cerebrovascular diseases.

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