Abstract #1228

Microstructural Brain Changes and Their Impact on Motor and Cognitive Functions After Hemorrhagic Stroke: A NODDI-Based Study

Hongwei Li¹, Sihui Wang^2,3, Yingjie Zhang⁴, Xiaochen Wang², Xuening Zhao², Lingxu Chen², Mengyuan Yuan², Zhensen Chen^1,5, He Wang^1,5, Yi Ju⁴, and Shengjun Sun^2,3

¹Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China, ²Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ³Department of Radiology, Beijing Neurosurgical Institute, Beijing, China, ⁴Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ⁵MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Shanghai, China

Synopsis

Keywords: Stroke, Neuro, ICH, diffusion, NODDI

Motivation: Current clinical practice monitors macroscopic changes in hematoma and edema through CT and MRI, research on microstructural injuries is limited.

Goal(s): Our study aims to use NODDI to evaluate microstructural changes post-ICH and their impact on motor and cognitive functions.

Approach: We enrolled 36 ICH patients, categorizing those with an mRS score >2 as having poor motor function prognosis, and calculated ICVF, ODI, and ISOVF from NODDI across brain regions.

Results: Damage to white matter in the affected hemisphere is correlated with short-term motor function impairments, whereas damage to deep gray matter in the same hemisphere is associated with declined cognitive outcome.

Impact: Early stage of ICH may result in the disruption of microstructural integrity within brain tissue.

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