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Abstract #1232

Evaluation of Cerebrovascular Reactivity Damage Using Resting-State BOLD in Symptomatic Patients with Unilateral MCA/ICA Occlusion

Yi Shan1, Yayan Yin1, Bixiao Cui1, Boyan Xu2, and Jie Lu1
1Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China, 2GE Healthcare, MR Research China, Beijing, China

Synopsis

Keywords: Stroke, Perfusion, Cerebrovascular Reactivity, BOLD, intracranial artery occlusion

Motivation: Cerebral vascular reserve (CVR) is an independent risk factor for patients with intracranial artery occlusion. CVR measurement using resting-state blood oxygenation level-dependent (RS BOLD) MRI shows clinical potential without gas-related tasks. Still, its feasibility has not been comprehensively evaluated.

Goal(s): Achieve clinically feasible CVR marker for risk stratification in patients with intracranial artery occlusion.

Approach: We adopted 45 patients with unilateral intracranial artery occlusion and 20 controls; 16 patients were followed up after surgery. Mean CVR and CVR-AI were calculated using RS BOLD in the perfusion territories of bilateral MCA.

Results: CVR-AI showed better diagnostic performance and potential value in predicting surgical outcomes.

Impact: This study proposes a new hemodynamic marker (CVR-AI) for risk stratification in patients with unilateral intracranial arterial occlusion and promotes the feasibility of measuring CVR using RS BOLD.

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