Keywords: Stroke, Perfusion, Cerebrovascular Reactivity, BOLD, intracranial artery occlusion
Motivation: Cerebral vascular reserve (CVR) is an independent risk factor for patients with intracranial artery occlusion. CVR measurement using resting-state blood oxygenation level-dependent (RS BOLD) MRI shows clinical potential without gas-related tasks. Still, its feasibility has not been comprehensively evaluated.
Goal(s): Achieve clinically feasible CVR marker for risk stratification in patients with intracranial artery occlusion.
Approach: We adopted 45 patients with unilateral intracranial artery occlusion and 20 controls; 16 patients were followed up after surgery. Mean CVR and CVR-AI were calculated using RS BOLD in the perfusion territories of bilateral MCA.
Results: CVR-AI showed better diagnostic performance and potential value in predicting surgical outcomes.
Impact: This study proposes a new hemodynamic marker (CVR-AI) for risk stratification in patients with unilateral intracranial arterial occlusion and promotes the feasibility of measuring CVR using RS BOLD.
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