Abstract #1236

Sex-specific brain patterns of pain with comorbidities in mice

Laetitia Degiorgis¹, Marion Sourty¹, Marion Rame¹, Mary Mondino¹, Vincent Noblet¹, Xiang Yi Kong², Andrea Rodriguez-Lopez³, Beltran Alvarez-Perez³, Christopher Sivert Nielsen^4,5, Rafael Maldonado^3,6, Bente Halvorsen^2,7, and Laura-Adela Harsan^1,8

¹Laboratory of Engineering, Informatics and Imaging (ICube), University of Strasbourg-CNRS, Strasbourg, France, ²Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ³Laboratory of Neuropharmacology-Neurophar, Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain, Barcelona, Spain, ⁴Division of Emergencies and Critical Care, Department of Pain Management and Research, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ⁵Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway, Oslo, Norway, ⁶Hospital del Mar Medical Research Institute (IMIM), Barcelona, Catalonia, Spain, Barcelona, Spain, ⁷Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway, Oslo, Norway, ⁸Department of Biophysics and Nuclear Medicine, University Hospital of Strasbourg, Strasbourg, France, Strasbourg, France

Synopsis

Keywords: Other Neurodegeneration, Neuroscience, Preclinical

Motivation: Chronic pain affects about 20% of European adults and is often accompanied by multiple comorbidities, increasing its overall impact. However, the mechanisms linking these conditions remain poorly understood.

Goal(s): Our study aimed to identify brain MRI biomarkers associated with pain and its comorbidities.

Approach: We explored a large cohort of male and female outbred mice with chronic pain, emotional, cognitive, and cardiovascular comorbidities, using resting-state functional images, DTI, and anatomical imaging.

Results: Our findings revealed a strong sex-dimorphism in brain organization among mice with comorbidities, with cardiovascular disease having a broader impact on males.

Impact: We studied a unique cohort of 300 outbred male and female mice to model human-like chronic pain and atherosclerosis, and our findings revealed sex-dependent brain architecture changes in mice with pain and comorbidities.

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