Keywords: Traumatic Brain Injury, Traumatic brain injury, pig, porcine, mTBI
Motivation: Mild traumatic brain injury (mTBI) is a global health challenge, yet its mechanism is not understood. Human post-impact imaging is multi-factorial and variable. Studies to unveil the local brain injury cascade are needed.
Goal(s): To present a porcine model of realistic human-mimicking head impacts with multiple MRI timepoints and histologic validation.
Approach: A linear impactor delivers a head impact leading to high rotational accelerations. We record biomechanics and perform detailed pre-/post-impact MR on a human scanner, ex vivo MR, coregistered histology, and finite-element modeling (FEM).
Results: We identify injury on in vivo and ex vivo MRI, predict with FEM, and validate with pathology.
Impact: Our novel large-animal linear-impact head impact model can detect injury with pre- and post-impact in vivo and ex vivo MRI, pathology, and finite-element modeling. This paradigm can uncover the microstructural, biomechanical, and molecular mechanism of head impact-induced brain injury.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords