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Abstract #1247

Metabolite T1 and T2 Relaxation Times in Healthy Aging

Saipavitra Murali-Manohar1,2, Helge J. Zöllner1,2, Kathleen E. Hupfeld1,2, Yulu Song1,2, Emily E. Carter3, Steve C. N. Hui4,5,6, Christopher W. Davies-Jenkins1,2, Dunja Simicic1,2, Aaron T. Gudmundson1,2,7, Gizeaddis L. Simegn1,2, Vivek Yedavalli1, Georg Oeltzschner1,2, Eric C. Porges3,8, and Richard A. E. Edden1,2
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, United States, 4Developing Brain Institute, Children’s National Hospital, Washington D. C., DC, United States, 5Departments of Radiology, The George Washington University School of Medicine and Health Sciences, Washington D. C., DC, United States, 6Departments of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington D. C., DC, United States, 7The Malone Center for Engineering in Healthcare, Johns Hopkins University, Baltimore, MD, United States, 8Center for Cognitive Aging and Memory, College of Medicine, University of Florida, Gainesville, FL, United States

Synopsis

Keywords: Aging, Aging, T1, T2, Relaxation times, MRS, Metabolites

Motivation: Metabolite relaxation measurements vary with age, in patterns that are distinct from changes in water relaxation, presumably reporting on specific cellular microenvironments.

Goal(s): To investigate metabolite T1 and T2 relaxation times at 3 T across the lifespan.

Approach: T1 and T2 relaxation times of metabolites were measured from an aging cohort consisting of 101 participants. Statistical analyses were conducted to identify correlations between T1/T2 and age, and between T1 and T2 for each metabolite of interest and tissue water.

Results: T1 and T2 were correlated in the aging cohort for tNAA2.0, tCr3.0 and Glx in both CSO and PCC.

Impact: Understanding the life-course of metabolite relaxation times is a critical pre-requisite to studies of metabolite concentration across the lifespan. We report correlations of T1 and T2 of metabolites with age, and between T1 and T2 in a large aging cohort.

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