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Abstract #1253

Studying brain microstructure in normal ageing using Neurite EXchange Imaging (NEXI) at 500 mT/m

Kwok-Shing Chan1,2, Hansol Lee1,2, Yixin Ma1,2, Aneri Bhatt1,2, Julianna Gerold1,2, Jeremy Ford1,2, Susie Yi Huang1,2, and Hong-Hsi Lee1,2
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Harvard Medical School, Boston, MA, United States

Synopsis

Keywords: Aging, Aging, Brain, Microstructure, Neuro, Gray Matter

Motivation: Recent quantitative MRI research suggests brain microstructure maturation may be independent of macroscopic structural alterations. NEXI is a novel method probing the water exchange between neurite and extracellular space in grey matter.

Goal(s): To observe the age-related alteration of exchange time from NEXI across various grey matter structures.

Approach: We acquired in vivo diffusion data on 34 healthy participants on the Connectome 2.0 scanner and compared the measured exchange time between three age groups (18-30; 31-60; 61-79 years).

Results: We found older adults have longer exchange time in various grey matter structures, driven by the reduction in neurite to extracellular exchange rate.

Impact: This study indicates age-related microstructure alterations may influence the water exchange in grey matter, providing a new imaging phenotype to study neurodegeneration. Developing NEXI normative data will strengthen our understanding of the association between water exchange and neurodegeneration disorders.

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