Abstract #1256

Developmental differences in haemodynamics drives temporal features of the cortical-depth-dependent BOLD response in neonates at 7T

Jucha Willers Moore¹, Elisabeth Pickles^2,3, Philippa Bridgen^2,3, Pierluigi Di Cio^2,3, Lucy Billimoria^2,3, Ines Tomazinho^1,2, Cidalia Da Costa^1,2, Dario Gallo^1,2, Grant Hartung^4,5,6, A David Edwards^1,2,7, Jo V Hajnal^3,8, Shaihan Malik^3,8, Kamil Uludag^9,10,11, Jonathan R Polimeni^5,6,12, and Tomoki Arichi^1,2,7

¹Early Life Imaging Research Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²Guy's and St Thomas' NHS Foundation Trust, King's College London, London, United Kingdom, ³London Collaborative Ultra high field System (LoCUS), King's College London, London, United Kingdom, ⁴Institute for Mechanics, Computational Mechanics Group, Technical University of Darmstadt, Darmstadt, Germany, ⁵Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁶Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁷MRC Centre for Neurodevelopmental Disorders, King's College London, London, United Kingdom, ⁸Imaging Physics and Engineering Research Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ⁹Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon, Korea, Republic of, ¹⁰Krembil Brain Institute, University Health Network, Toronto, ON, Canada, ¹¹Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ¹²Harvard-MIT Program in Health Sciences and Technology, Massachusetts Institute of Technology, Charlestown, MA, United States

Synopsis

Keywords: Mesoscale: columns and layers, Neonatal, Biophysics, Ultra-high field, Normal Development

Motivation: Many biophysical, neurovascular and physiological factors determining BOLD response characteristics are altered during the neonatal period. It is unclear how each factor affects the immature BOLD response.

Goal(s): To understand whether altered physiology, neuronal activity or neurovascular coupling predict neonatal specific features of the neonatal BOLD response.

Approach: Cortical-depth-dependent BOLD responses were defined in neonates and adults using GRE-EPI fMRI at 7T. Temporal and amplitude features were predicted with the laminar BOLD response model and infinite cylinder model.

Results: Distinct cortical-depth-dependent neonatal BOLD response features can be largely accounted for by altered haemodynamics and baseline physiology in the developing brain.

Impact: Developmental differences in haemodynamics and cerebral physiology significantly alter temporal and amplitude features of the cortical-depth-dependent BOLD response in neonates. This has clear implications for using fMRI to study the emergence of brain activity across this critical period.

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