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Abstract #1261

Mesoscale fMRI at ultra-high spatiotemporal resolutions using 3D Echo Planar TIme- and DYnamic-resolved Imaging (TIDY)

Zijing Dong1,2, Daniel Haenelt1,2, Shahin Nasr1,2, Bruce R. Rosen1,2,3, Lawrence L. Wald1,2,3, Jonathan R. Polimeni1,2,3, and Fuyixue Wang1,2
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Department of Radiology, Harvard Medical School, Boston, MA, United States, 3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: Mesoscale: columns and layers, fMRI Acquisition, Mesoscale

Motivation: Mesoscale fMRI enables investigation of brain’s function at cortical layers/columns.

Goal(s): To address the major challenges in achieving mesoscale fMRI at <0.5-mm-iso (<0.1-µL): i) high spatial-encoding burden, limiting coverage and spatiotemporal resolutions; ii) severe distortion and T2/T2*-blurring; iii) low SNR.

Approach: We introduce a novel acquisition/reconstruction technique, named 3D echo-planar Time- and Dynamic-resolved imaging (TIDY), which leverages multi-dimensional encoding design with time- and dynamic-resolved reconstruction to achieve distortion-free fMRI at ultra-high spatiotemporal resolutions.

Results: We achieved distortion-free whole-brain fMRI at 500-um-iso with an 885-ms volume-TR, resulting in robust activation within 4.5-min, and demonstrated fMRI at 340-um-iso with robust visual-pattern activation across cortical layers.

Impact: We introduce a novel acquisition/reconstruction technique, named 3D echo planar TIme- and Dynamic-resolved imaging (TIDY), to achieve distortion-free mesoscale fMRI at ultra-high spatiotemporal resolutions (e.g., whole-brain 500-um-iso at 885-ms volume-TR; partial-brain 340-um-iso at 1.2-s volume-TR).

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Keywords