Abstract #1270

Quantitative Susceptibility Mapping and R2* of Ischemia-reperfusion Injury and its Relationship with Reactive Oxygen Species Activity

Marina Michel Awad¹, Sophia Swago¹, Chiara Camillo², Elizabeth Thompson¹, Abhijit Bhattaru³, Brianna F Moon¹, Giovanni Ferrari², Estibaliz Castillero², Evan Gallagher⁴, Meagan McManus⁴, Victor A Ferrari⁵, Robert Gorman⁶, Cory Tschabrunn⁵, Robert H Mach³, Joel S Karp³, Paco E Bravo³, and Walter R Witschey³

¹Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ²Surgery, Columbia University, New York, NY, United States, ³Radiology, University of Pennsylvania, Philadelphia, PA, United States, ⁴Center for Mitochondrial and Epigenomic Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States, ⁵Medicine, University of Pennsylvania, Philadelphia, PA, United States, ⁶Surgery, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Susceptibility/QSM, Ischemia, Iron, reperfusion injury

Motivation: There is a need for specific imaging of ischemia-reperfusion injury (IRI) as it initiates infarct iron deposition, catalyzing reactive oxygen species (ROS) production and heart failure.

Goal(s): Our goal was to assess and image the relationships between susceptibility, R2*, and ROS activity.

Approach: Six swine with IRI were imaged to quantify iron using QSM and R2*, and to measure ROS activity.

Results: Regions of hemorrhage and infarct had higher susceptibility, R2* and ROS activity compared to remote regions. There was a positive correlation between infarct ROS activity and R2* in the hemorrhage, and between infarct ROS activity and susceptibility in the hemorrhage.

Impact: The observed associations between magnetic susceptibility and R2* with ROS activity allows for better understanding of IRI and potential to develop new targeted interventions. This suggests that iron could be a catalyst for ROS production in ischemia-reperfusion injury.

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