Abstract #1273

Open-Source Implementation for X-Nuclear and Multi-Site Sequences within the Pulseq Framework

Xiaoxi Liu¹, Di Cui¹, Peder E.Z. Larson¹, Dirk Mayer², Jon-Fredrik Nielsen³, Rolf F. Schulte⁴, Changhua Mu¹, Lucas Carvajal¹, Duan Xu¹, Jeremy W. Gordon¹, Daniel B. Vigneron¹, Andreas Korzowski⁵, Robert R. Flavell¹, and Zhen J. Wang¹

¹Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Department of Diagnostic Radiology and Nuclear Medicine, School of Medicine, University of Maryland, Baltimore, MD, United States, ³Functional MRI Laboratory, Department of Radiology, Universisty of Michigan, Ann Arbor, MI, United States, ⁴GE HealthCare, Munich, Germany, ⁵Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Synopsis

Keywords: Software Tools, Pulse Sequence Design, Software Tools

Motivation: Support X-nuclear and vendor-neutral acquisitions for sharing and scanning across scanners and sites.

Goal(s): Build a GE interpreter for X-nuclear acquisition using Pulseq framework; create a modular sequence that can support fast and flexible X-nuclear acquisition.

Approach: X-nuclei capabilities were built into TOPPE GE interpreter. A modular 2D GRE spiral sequence was developed, integrating a flexible RF and readout module, and evaluated by both phantom and in-vivo studies.

Results: Data from ³¹P, ²H, and ¹³C phantoms, multi-site ¹³C phantom, ²H-MRS brain volunteer, and hyperpolarized [1-¹³C]pyruvate animal studies demonstrated the feasibility, flexibility and reproducibility of the TOPPE MNS GE interpreter and modular spiral sequence.

Impact: X-nuclear sequence developers can now more easily transfer their sequences across vendors and software for multi-site studies.

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