Abstract #1280

Efficient 5D Motion Resolved Imaging: Assessing Spatial Resolutions for Faster Acquisition Without Compromising LV Ejection Fraction Accuracy

Jerome Yerly^1,2, Augustin C Ogier¹, Christopher W Roy¹, Katerina Eyre³, Bastien Milani¹, Ruud B van Heeswijk¹, and Matthias Stuber^1,2

¹Lausanne University Hospital, Lausanne, Switzerland, ²Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, ³Research Institute, McGill University Health Centre, Montreal, QC, Canada

Synopsis

Keywords: Sparse & Low-Rank Models, Motion Correction, Ejection Fraction, Cardiac Function, Left Ventricle Ejection Fraction, Self-Gating, Motion Compensation, Motion Fields, Compressed Sensing, Free-running, Radial MRI, Accuracy, Precision, 3D Radial Trajectory, 5D whole-heart MRI

Motivation: Accurate LVEF assessment is essential for evaluating cardiac function, but conventional cardiac MRI techniques are time-consuming, operator-dependent, and have suboptimal anisotropic spatial resolution.

Goal(s): To determine if accurate LVEF measurements can be achieved with shorter acquisition times and reduced spatial resolution by leveraging a 5D free-running framework with inter-bin motion compensation (FRF-MC).

Approach: FRF-MC was optimized and compared to the original 5D method at three spatial resolutions and against a reference 2D cine in 9 healthy participants.

Results: FRF-MC maintained accurate LVEF measurements across all investigated spatial resolutions with superior image quality, enabling rapid, free-breathing MRI acquisitions in as little as 2.5 minutes.

Impact: Leveraging inter-bin motion compensation in the free-running framework with lower spatial resolution enables rapid, high-quality, free-breathing cardiac MRI in under 2.5 minutes without compromising left ventricular ejection fraction measurement accuracy. This advancement may enhance clinical workflows and improve patient comfort.

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